Case Study #2 – Human Joint Mobility Supplements

Toxicology, tolerability, and pharmacokinetics study on cannabidiol-glucosamine (CBD-Gln) formula to treat osteoarthritis symptoms

Toxicology and tolerability are crucial parameters in the development of any drug or dietary supplement. Unsafe or intolerable developments can not pass the pre-clinical stage and can not reach the market place.

Pharmacokinetic (Pk) parameters tells the time course of an ingredient (drug or dietary ingredient) absorption, distribution, metabolism, and excretion along time. The Pk tells about the rate of absorption, especially when the ingredient reaches its maximal concentration in the plasma or target organs and how long it stays in the plasma/target organs.

In our trials, we checked the toxicity and tolerability of CBD-Gln formulae and adjusted the formula in a way that it will penetrate the plasma/target organ in high doses over time.